HCID 10244361, compound → HCID 86620054, compound

HRID 1034465Notes

Reaction equation

HRID 1034465 reaction equation
[C:1]([CH2:6][CH2:7]C1C=C2C(=CC=1)NC=C2CCN)([O:3]CC)=[O:2].[CH:20](/[O:27]S(O)(=O)=O)=N/N/C(/N)=N/O.C([OH:35])(C)C.CCOCC>O>[OH2:2].[C:20]([OH:27])(=[O:35])/[CH:7]=[CH:6]\[C:1]([OH:3])=[O:2]

Participants

5

Reactant 3

HCID 10244361HCID 10244361, compoundHCID 22147583Diethyl ether 2-propanolHCID 178513442HCID 178513442, compound

Product 1

HCID 86620054HCID 86620054, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared from 2-[5-(2-(carboethoxy)ethyl)-1H-indol-3-yl]ethylamine and hydroxy guanidine sulphate using the procedure described for Example 6. The hydrogen maleate salt was prepared, mp 147°-148° C. (isopropylalcohol/ether); (Found: C, 53.89; H, 5.47; N, 17.67. C14H17N5O. C4H4O4. 0.75 H2O requires C, 53.93; H, 5.65; N, 17.47%); δ(360 MHz, D2O) 3.12 (2H, t, J=6.9 Hz, CH2); 3.17 (4H, t, J=4.1 Hz, 2 of CH2); 3.29 (2H, t, J=6.9 Hz, CH2); 7.11 (1H, dd, J=1.5 and 8.4 Hz, aromatic-H); 7.27 (1H, s, aromatic-H); 7.40 (1H, s, aromatic-H); 7.44 (1H, d, J=8.4 Hz, aromatic-H).

Sources & evidence

ORD record
ord-74ff1b691f62468e82970efffa17f5fc
Source dataset
uspto-grants-1994_05
Patent number
US05317103

Reaction notes

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