Potassium Hydroxide → (S)-5-Methyl-3-nitromethyl-hexanoic acid dipotassium salt

HRID 1034570Notes

Reaction equation

HRID 1034570 reaction equation
C([O:3][C:4](=[O:15])[CH2:5][C@@H:6]([CH2:11][N+:12]([O-:14])=[O:13])[CH2:7][CH:8]([CH3:10])[CH3:9])C.[OH-].[K+:17]>O>[K+:17].[K+:17].[CH3:9][CH:8]([CH3:10])[CH2:7][C@H:6]([CH2:11][N+:12]([O-:14])=[O:13])[CH2:5][C:4]([O-:15])=[O:3].[CH3:9][CH:8]([CH3:10])[CH2:7][C@H:6]([CH2:11][N+:12]([O-:14])=[O:13])[CH2:5][C:4]([O-:15])=[O:3]

Participants

4

Reactant 2

HCID 14797Potassium Hydroxide2×HCID 29984078(S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester

Product 1

HCID 131730882(S)-5-Methyl-3-nitromethyl-hexanoic acid dipotassium salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

830 mg of (S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester (VIII, R1=ethyl) were suspended in 0.8 mL of H2O. 900 mg of 50% aqueous KOH were added. After 5 h at 25° C. conversion was complete (determination by HPLC). The solvent was removed under reduced pressure to give a solid consisting of the title compound and minor amounts of KOH.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customto give a solid

Sources & evidence

ORD record
ord-7a302eaf53494bc18899a86728c391f3
Source dataset
uspto-grants-2013_10
Patent number
US08546112B2

Reaction notes

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