反应详情

A solution of EXAMPLE 24E (766 mg, 1.88 mmol) in a mixture of dichloromethane (30 mL) and methanol (30 mL) was treated with 10% palladium on carbon (150 mg) under hydrogen at ambient temperature for 6 hours. Solid material was filtered off and the filtrate concentrated to provide the title compound (564 mg, 100%). 1H NMR (DMSO-d6): 1.67-1.79 (m, 4H), 2.01-2.11 (m, 1H), 2.22-2.32 (m, 1H), 2.38-2.43 (m, 2H), 2.85-2.91 (m, 2H), 3.16-3.26 (m, 2H), 3.30 (dd, J=11.0, 8.0 Hz, 1H), 3.46 (dd, J=11.2, 7.5 Hz, 1H), 3.78 (s, 3H), 3.81-3.88 (m, 1H).

1. filtrationSolid material was filtered off
2. concentrationthe filtrate concentrated