HCID 136506542, compound → HCID 135948891, compound

Participants

Reaction Steps

A solution of Example 39 (90 mg, 0.2 mmol) in trifluoroacetic acid (10 mL) was stirred at 50° C. for 4 hours. After cooling, the mixture was concentrated and the residue purified by HPLC (Zorbax, C-18, 250×2.54 column, Mobile phase A 0.1% trifluoroacetic acid in water, B 0.1% trifluoroacetic acid in acetonitrile, 0-100% gradient) to provide 70 mg of the title compound as the trifluoroacetate salt. 1H NMR (CD3OD) □ 1.53-1.63 (m, 2H), 1.71-1.80 (m, 2H), 2.42-2.54 (m, 4H), 3.92 (s, 3H), 4.21 (s, 2H), 7.52-7.65 (m, 4H).

Provenance & Evidence