Ethyl isocyanate → HCID 136660218, compound

Participants

Reaction Steps

To a solution of EXAMPLE 56E (3.8 g, 7.1 mmol) in pyridine (100 mL) was added ethyl isocyanate (1.6 mL, 21 mmol) and the solution stirred at ambient temperature for 24 hours. The mixture was heated at reflux overnight, cooled, concentrated and the residue purified by flash chromatography on silica gel using ethyl acetate to give 3.4 g (85%) of the title compound. MS (DCI): m/z 563 (M+H)+.

Provenance & Evidence