Ammonia → HCID 178518580, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of Example 95A (150 mg) and trimethylsily azide (582 mg) in toluene (20 ml) was added dibutyltin oxide (28 mg). The mixture was heated at 100° C. for 3 days. Solid material was collected by filtration, washed with methanol and dried to give Example 95. Yield: 100 mg. MS (DCI/NH3) m/z 402 (M+H)+; 1H NMR (500 MHz, CD3OD): δ 1.81 (s, 2H), 1.92 (m, 1H), 2.02-2.11 (m, 1H), 2.35-2.44 (m, 4H), 2.51 (m, 2H), 2.91 (br s, 2H), 3.84-3.90 (m, 1H), 5.37 (br s, 1H), 5.51 (s, 2H), 5.51 (s, 2H), 7.30 (m, 2H), 7.97 (m, 2H),

Provenance & Evidence