Trifluoroacetic acid → HCID 68582561, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 88B (1.57 g, 7.9 mmol) in dichloromethane (25 mL) was treated with trifluoroacetic acid (5 mL) for 30 min at rt. The reaction mixture was concentrated to dryness. To the residue was added 2-fluoro-nicotinonitrile (1.0 g, 8.19 mmol) and diisopropyl ethylamine (3.2 mL) in tetrahydrofuran (8 mL). The reaction mixture was heated at 115° C. for 10 min under microwave condition. The mixture was concentrated to dryness, and the residue was chromatographed using hexane/ethyl acetate (9:1-6:1) to give the title compound (806 mg, 51%). MS (DCI/NH3) m/z 202 (M+1)+. 1HNMR (400 MHz, CDCl3) δ ppm 1.98 (s, 2 H) 3.67 (d, J=10.13 Hz, 1 H) 3.91 (dd, J=7.98, 1.53 Hz, 1 H) 3.96 (m, 2 H) 4.69 (s, 1 H) 5.16 (s, 1 H) 6.64 (dd, J=7.67, 4.91 Hz, 1 H) 7.71 (dd, J=7.36, 1.84 Hz, 1 H) 8.26 (dd, J=4.60, 1.84 Hz, 1 H).

Provenance & Evidence