3-Hydroxy-5-chloropyridine → HCID 64601948, compound

HRID 1035002Notes

Reaction equation

HRID 1035002 reaction equation
F[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Cl:10][C:11]1[CH:12]=[C:13]([OH:17])[CH:14]=[N:15][CH:16]=1>>[Cl:10][C:11]1[CH:12]=[C:13]([O:17][C:2]2[N:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])[CH:14]=[N:15][CH:16]=1

Participants

3

Reactant 2

HCID 5823053-Hydroxy-5-chloropyridineHCID 27832543-Cyano-2-fluoropyridine

Product 1

HCID 64601948HCID 64601948, compound

Procedure

2-Fluoro-nicotinonitrile was reacted with 5-chloro-pyridin-3-ol according to the method of Example 85A to provide the title compound. MS (DCI/NH3) m/z 232 (M)+, 234(M+2)+.

Sources & evidence

ORD record
ord-c43c2051a65d4146bfe95037a0c6ffda
Source dataset
uspto-grants-2013_10
Patent number
US08546374B2

Reaction notes

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