Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile | HCID 2733849 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86082307 | HCID 86082307 | 76% |
Reaction Steps
A mixture of 2,6-dichloro-5-fluoro-nicotinonitrile (900 mg, 5.7 mmol), 2,2,2-trifluoro-ethanol (570 mg, 5.7 mmol), and NaH (60%) (273 mg, 6.8 mmol) in N,N-dimethylformamide (15 mL) was heated at 120° C. overnight. The reaction mixture was poured into water, and extracted with ethyl acetate (2×). The solvent was removed to give the title compound (1100 mg, 76%). MS (DCI/NH3) m/z 255 (M)+, 257 (M+2)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08546374B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-adc8f02f252b438fabfd9c04ffe94645 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
