1,1,1-Trifluoro-2-iodoethane → 1-Bromo-4-fluoro-2-(2,2,2-trifluoroethoxy)benzene

HRID 1035013Notes

Reaction equation

HRID 1035013 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[F:10][C:11]([F:15])([F:14])[CH2:12]I>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH2:12][C:11]([F:15])([F:14])[F:10]

Participants

3

Reactant 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 27246002-Bromo-5-fluorophenol

Product 1

HCID 579845111-Bromo-4-fluoro-2-(2,2,2-trifluoroethoxy)benzene

Procedure

2-Bromo-5-fluoro-phenol was reacted with 1,1,1-trifluoro-2-iodo-ethane according to the method of Example 108A to provide the title compound. MS (DCI/NH3) m/z 273 (M)+, 275 (M+2)+.

Sources & evidence

ORD record
ord-636f113a787b4f88a9fd9db32f98d4ba
Source dataset
uspto-grants-2013_10
Patent number
US08546374B2

Reaction notes

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