6-fluoroindan-1-one O-methyloxime → 6-Fluoro-2,3-dihydro-1H-inden-1-amine

HRID 1035041Notes

Reaction equation

HRID 1035041 reaction equation
CO[N:3]=[C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[CH2:6][CH2:5]1>[Ni]>[F:13][C:10]1[CH:11]=[C:12]2[C:7]([CH2:6][CH2:5][CH:4]2[NH2:3])=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 860822766-fluoroindan-1-one O-methyloxime

Product 1

HCID 154081276-Fluoro-2,3-dihydro-1H-inden-1-amine

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

The product of Example 135A and Raney/nickel were processed according to the method of Example 131C to provide the product. MS (ESI+) m/z 152 (M+H)+;

Workup

  1. customto provide the product

Sources & evidence

ORD record
ord-6d1fa4ad35d64e0aa2b91d7ab3970ede
Source dataset
uspto-grants-2013_10
Patent number
US08546374B2

Reaction notes

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