HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1035046Generated: November 2, 2026
Formaldehyde → 1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one
https://huagongshe.com/reaction/1035046
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | spiro[indene-1,4'-piperidin]-3(2H)-one | HCID 18467061 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one | HCID 53712826 | — |
Reaction Steps
To the product of Example 138A were added formic acid (88% sol, 0.64 g) and formaldehyde (36% sol, 0.45 g) and stirred at 120° C. overnight. The crude product was used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08546374B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-11d1fdd7e1964928aad7f601d532e380 |
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| Source note | uspto-grants-2013_10 |
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