2-Chloronicotinonitrile → HCID 46312070, compound

HRID 1035058Notes

Reaction equation

HRID 1035058 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1B(O)O>>[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:2]1[N:3]=[CH:4][CH:5]=[CH:6][C:7]=1[C:8]#[N:9]

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 27343542-Fluorophenylboronic acid

Product 1

HCID 46312070HCID 46312070, compoundYield 74%

Procedure

Prepared in 74% yield from 2-chloro-3-cyanopyridine and 2-fluorophenylboronic acid according to the procedure described for Example 153A. MS (ESI+) m/z 199.0 (M+H)+; 1H NMR (CDCl3) δ 7.22-7.34 (m, 2H), 7.42-7.55 (m, 2H), 7.57-7.63 (m, 1H), 8.09 (dd, J=7.8, 1.7 Hz, 1H), 8.91 (dd, J=4.7, 1.7 Hz, 1H).

Sources & evidence

ORD record
ord-04ed065af64746058b9eac4dd45f5837
Source dataset
uspto-grants-2013_10
Patent number
US08546374B2

Reaction notes

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