HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinonitrile → 2-(2-Phenoxy-phenyl)nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinonitrile | HCID 81079 | — |
| Reactant | (2-Phenoxyphenyl)boronic acid | HCID 2773559 | — |
| Product | 2-(2-Phenoxy-phenyl)nicotinonitrile | HCID 39736277 | 50% |
Reaction Steps
Prepared in 50% yield from 2-chloro-3-cyanopyridine and 2-phenoxyphenylboronic acid according to the procedure described for Example 153A. MS (ESI−) m/z 273.0 (M+H)+; 1H NMR (CDCl3) δ 6.94 (d, J=7.1 Hz, 1H), 7.06-7.11 (m, 3H), 7.20-7.44 (m, 5H), 7.54 (dd, J=7.5, 1.7 Hz, 1H), 8.00 (dd, J=8.1, 2.0 Hz, 1H), 8.86 (dd, J=5.1, 1.7 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546374B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-8e76a41e1e3e4ea0af133050383ca98f |
| Source note | uspto-grants-2013_10 |