(Pyrimidin-5-yl)boronic acid → HCID 68583352, compound

HRID 1035108Notes

Reaction equation

HRID 1035108 reaction equation
[N:1]1[CH:6]=[C:5](B(O)O)[CH:4]=[N:3][CH:2]=1.Cl[C:11]1[C:16]([CH2:17][NH:18][C:19]2[N:23]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[C:26]([Cl:31])[C:25]=3[Cl:32])[N:22]=[N:21][N:20]=2)=[CH:15][CH:14]=[CH:13][N:12]=1>>[Cl:32][C:25]1[C:26]([Cl:31])=[C:27]([F:30])[CH:28]=[CH:29][C:24]=1[N:23]1[C:19]([NH:18][CH2:17][C:16]2[C:11]([C:5]3[CH:6]=[N:1][CH:2]=[N:3][CH:4]=3)=[N:12][CH:13]=[CH:14][CH:15]=2)=[N:20][N:21]=[N:22]1

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 59264553HCID 59264553, compound

Product 1

HCID 68583352HCID 68583352, compound

Procedure

The title compound was prepared from pyrimidine-5-boronic acid and the product of Example 285B using General Procedure 6. MS (ESI+) m/z 417.2 (M+H)+; Rt=1.50 min. 1H-NMR (400 MHz DMSO-d6) δ 5.80 (s, 2H), 7.45 (t, J=8.9 Hz, 1H), 7.54 (m, 2H), 7.63 (m, 1H), 8.71 (dd, J=2.6 Hz, J=3.8 Hz, 1H), 9.02 (s, 3H), 9.27 (s, 1H).

Sources & evidence

ORD record
ord-52d7c4fe3dd84a54b290971858d36bf5
Source dataset
uspto-grants-2013_10
Patent number
US08546374B2

Reaction notes

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