Hydrochloric Acid → HCID 66655835, compound

Participants

Reaction Steps

Intermediate 23A (1.5 g, 2.7 mmol) was dissolved in MeOH (20 mL), a 4.0 M solution of HCl in MeOH (2 mL) was added and the reaction mixture was stirred at RT for one hour. The mixture was concentrated and the residue was co-evaporated with EtOH several times. The residue was triturated with THF and then DCM (50 mL) and aqueous K2CO3 (5 g dissolved in 5 mL water) were added. After phases were separation, the organic phase was dried (Na2CO3) and the solvent was removed by evaporation. There was obtained 0.55 g (71%) of 23B.

Provenance & Evidence