HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 66653277, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Methoxy-2-(trifluoromethyl)benzaldehyde | HCID 2778286 | — |
| Reactant | 3-Fluoro-4-((4-methylpiperazin-1-yl)methyl)phenol | HCID 58043126 | — |
| Reactant | tert-Butyl 3-(3-fluoro-4-((4-methylpiperazin-1-yl)methyl)phenoxy)azetidine-1-carboxylate | HCID 58043154 | — |
| Reactant | 1-(4-(Azetidin-3-yloxy)-2-fluorobenzyl)-4-methylpiperazine | HCID 66653480 | — |
| Product | HCID 66653277 | HCID 66653277 | 20% |
Reaction Steps
Using similar protocols as described in Examples 29A, 29B, 29C and 29D employing pyrrolidine and 4-methoxy-2-(trifluoromethyl)benzaldehyde as starting materials afforded 0.58 g (20%) of 45A as an oil. 1H NMR (500 MHz, CDCl3): δ 1.78 (s, 4H), 2.53 (d, 4H), 3.71 (s, 2H), 3.80 (m, 2H), 3.93 (m, 2H), 5.01 (m, 1H), 6.87 (dd, 1H), 7.00 (d, 1H), 7.64 (d, 1H), MS (APCI+) m/z 301 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546375B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-dead17049d1a410894c783ab1f9fb40a |
| Source note | uspto-grants-2013_10 |