HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 1-(4-(Azetidin-3-yloxy)-2-chlorophenyl)-N,N-dimethylmethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 2-Chloro-4-hydroxybenzaldehyde | HCID 185363 | — |
| Reactant | tert-Butyl 3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidine-1-carboxylate | HCID 58043102 | — |
| Reactant | 1-(4-(Azetidin-3-yloxy)-2-methylphenyl)-N,N-dimethylmethanamine | HCID 66656350 | — |
| Product | 1-(4-(Azetidin-3-yloxy)-2-chlorophenyl)-N,N-dimethylmethanamine | HCID 66653489 | 10% |
Reaction Steps
Using similar protocols as described in Examples 20A, 20B and 20C employing dimethylamine and 2-chloro-4-hydroxybenzaldehyde as starting material afforded 0.13 g (10%) of 47A as an oil. 1H NMR (500 MHz, CDCl3): δ 2.26 (s, 6H), 3.45 (s, 2H), 3.78 (m, 2H), 3.92 (m, 2H), 4.96 (m, 1H), 6.65 (d, 1H), 6.76 (d, 1H), 7.27 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546375B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-f01b130c04ae47c8a778dc50d8487c7a |
| Source note | uspto-grants-2013_10 |