Ammonia → HCID 59548516, compound

HRID 1035300Notes

Reaction equation

HRID 1035300 reaction equation
C([O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:17]#[N:18])C.N>CO.[Ni]>[CH:16]1[C:11]2[C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4](=[O:3])[NH:18][CH2:17][C:12]=2[CH:13]=[N:14][CH:15]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 66769548HCID 66769548, compound

Product 1

HCID 59548516HCID 59548516, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of Example 180C (29.4 g, 0.117 mol) and Raney®-nickel (30 g) in 2 L of methanol saturated with NH3 was stirred under H2 (50 psi) at 50° C. for 24 hours. After cooling and removal of the catalyst, the mixture was concentrated under reduced pressure to obtain the title compound which was used without further purification.

Workup

  1. temperatureAfter cooling
  2. customremoval of the catalyst
  3. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5066493f0c9045eb9711fc2072dcd3ae
Source dataset
uspto-grants-2013_10
Patent number
US08546377B2

Reaction notes

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