HCID 67248450, compound → HCID 67250238, compound

Participants

Reaction Steps

To a solution of Example 237A (60.8 mg, 0.264 mmol) in tetrahydrofuran (20 mL) was added to 5% Pd—C (wet, 18.24 mg, 0.171 mmol). The solution was stirred under H2 (30 psi) for 16 hours at ambient temperature. The solution was then filtered through a nylon membrane and concentrated. Purification via HPLC (ammonium acetate method) afforded the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 6.72-6.92 (m, 3H), 4.27-4.42 (m, 1H), 4.04-4.16 (m, 1H), 2.69-3.15 (m, 7H), 2.43-2.59 (m, 2H), 1.76-2.03 (m, 2H), 1.08 (t, J=7.54 Hz, 3H); MS (ESI+) m/z 233 (M+H)+.

Provenance & Evidence