HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-tert-Butyl-5-isocyanato-1-p-tolyl-1H-pyrazole → 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-tert-Butyl-5-isocyanato-1-p-tolyl-1H-pyrazole | HCID 17987855 | — |
| Reactant | 8-(4-amino-3-fluorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-one | HCID 46900932 | — |
| Product | 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenyl)urea | HCID 46899945 | — |
Reaction Steps
Method F2 was used with 8-(4-amino-3-fluorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-one and 3-tert-butyl-5-isocyanato-1-p-tolyl-1H-pyrazole to afford the title compound as an off-white solid. Yield: 35 mg (42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546387B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-c1b1f9b9665546acb7385ed7ba776536 |
| Source note | uspto-grants-2013_10 |