3-tert-Butyl-5-isocyanato-1-p-tolyl-1H-pyrazole → 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(2-methyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

HRID 1035445Notes

Reaction equation

HRID 1035445 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[O:5][C:6]1[C:15]2[N:14]=[C:13]([CH3:16])[C:12](=[O:17])[NH:11][C:10]=2[N:9]=[CH:8][CH:7]=1.[C:21]([C:25]1[CH:29]=[C:28]([N:30]=[C:31]=[O:32])[N:27]([C:33]2[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][CH:34]=2)[N:26]=1)([CH3:24])([CH3:23])[CH3:22]>>[C:21]([C:25]1[CH:29]=[C:28]([NH:30][C:31]([NH:1][C:2]2[CH:20]=[CH:19][CH:18]=[C:4]([O:5][C:6]3[C:15]4[N:14]=[C:13]([CH3:16])[C:12](=[O:17])[NH:11][C:10]=4[N:9]=[CH:8][CH:7]=3)[CH:3]=2)=[O:32])[N:27]([C:33]2[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][CH:34]=2)[N:26]=1)([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 179878553-tert-Butyl-5-isocyanato-1-p-tolyl-1H-pyrazoleHCID 469015948-(3-aminophenoxy)-2-methylpyrido[2,3-b]pyrazin-3(4H)-one

Product 1

HCID 469004271-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(2-methyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)ureaYield 57%

Procedure

Method F2 was used with 8-(3-aminophenoxy)-2-methylpyrido[2,3-b]pyrazin-3(4H)-one and 3-tert-butyl-5-isocyanato-1-p-tolyl-1H-pyrazole to afford the title compound as a white solid (89 mg, 57%).

Sources & evidence

ORD record
ord-57f6add136f74642a1c2677737c3f691
Source dataset
uspto-grants-2013_10
Patent number
US08546387B2

Reaction notes

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