HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → 1-(4-(3-Amino-2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)naphthalen-1-yl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-5-(trifluoromethyl)phenyl isocyanate | HCID 2733380 | — |
| Reactant | 3-amino-8-(4-aminonaphthalen-1-yloxy)pyrido[2,3-b]pyrazin-2(1H)-one | HCID 46901252 | — |
| Product | 1-(4-(3-Amino-2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)naphthalen-1-yl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea | HCID 44132374 | 38% |
Reaction Steps
Method F2 was used with 3-amino-8-(4-aminonaphthalen-1-yloxy)pyrido[2,3-b]pyrazin-2(1H)-one and 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene to afford the title compound as a yellow/orange solid (31 mg, 38%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546387B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-efb03105b5fb483e9a223d60564d922d |
| Source note | uspto-grants-2013_10 |