HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloromethyl Methyl Ether → Ethyl 3-tert-butyl-1-(methoxymethyl)-1H-pyrazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloromethyl Methyl Ether | HCID 7864 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Ethyl 3-tert-butyl-1H-pyrazole-5-carboxylate | HCID 2743509 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-tert-butyl-1-(methoxymethyl)-1H-pyrazole-5-carboxylate | HCID 59588852 | — |
Reaction Steps
Method I was used with ethyl 3-tert-butyl-1H-pyrazole-5-carboxylate (1078 mg, 5.49 mmol), caesium carbonate (2.89 g, 8.87 mmol) and chloro(methoxy)methane (426 μl, 5.60 mmol). 16 hours reaction time. Column eluent: 0→10% EtOAc in CH2Cl2. Yield: 485 mg (37%) of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546387B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-740769e9cb7e46af93661feb4499a441 |
| Source note | uspto-grants-2013_10 |