Sodium Carbonate → HCID 25165368, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 50 mg (0.157 mmol) of 4-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-6-ethylpyrimidin-2-ylamine, 56 mg (0.282 mmol) of methylpyrazole-4-boronic acid pinacol ester, 9 mg (0.008 mmol) of tetrakis(triphenylphosphine)palladium(0) and 0.45 ml of a 2M Na2CO3 solution (0.900 mmol) in 0.6 ml of DMF is heated for 30 min at 120° C. in the microwave. The reaction mixture is filtered, the filter cake is washed with MeOH, and the filtrate is evaporated in vacuo. The residue is purified by preparative HPLC, giving 4-ethyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-ylamine as a colourless solid, ESI 320.

Provenance & Evidence