Benzyloxy-3-nitro[1,5]naphthyridin-4-amine → Benzyloxyquinoline-3,4-diamine

HRID 1035487ノート

反応式

HRID 1035487 の反応式
[CH2:1]([O:8][C:9]1[C:18]([N+:19]([O-])=O)=[C:17]([NH2:22])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:30][C:31]1[C:40]([N+:41]([O-])=O)=[C:39]([NH2:44])[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][N:37]=2)[N:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:1]([O:8][C:9]1[C:18]([NH2:19])=[C:17]([NH2:22])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:30][C:31]1[C:40]([NH2:41])=[C:39]([NH2:44])[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][N:37]=2)[N:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

4

反応物 2

HCID 66649873Benzyloxy-3-nitro[1,5]naphthyridin-4-amineHCID 66649911Benzyloxy-3-nitroquinolin-4-amine

生成物 2

HCID 66958435Benzyloxyquinoline-3,4-diamineHCID 67157263Benzyloxy[1,5]naphthyridine-3,4-diamine

実験手順

In steps (6) and (7) of Reaction Scheme IV, the hydroxy group of a benzyloxy-3-nitroquinolin-4-amine or benzyloxy-3-nitro[1,5]naphthyridin-4-amine of Formula XL is protected to provide a compound of Formula XLI, which is reduced to provide a benzyloxyquinoline-3,4-diamine or benzyloxy[1,5]naphthyridine-3,4-diamine of Formula XLII. Steps (6) and (7) of Reaction Scheme IV can be carried out according to the methods described in steps (2) and (3) of Reaction Scheme I.

後処理

  1. customto provide a compound of Formula XLI, which

出典と根拠

ORDレコード
ord-66b1a285af004477a806c2d0c5b635fa
出典データセット
uspto-grants-2013_10
特許番号
US08546383B2

反応ノート

読み込み中…