5-Oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate → 6-(3-Hydroxyphenyl)-3,4-dihydronaphthalene-1(2H)-one

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Reaction Steps

The compound is prepared by the reaction of 5-oxo-5,6,7,8-tetrahydronaphthalene-2-yl trifluoromethanesulfonate (1.78 g, 6.04 mmol, 1 eq) with 3-hydroxyphenylboric acid (1 g, 7.25 mmol, 1.2 eq) according to method A within 4 h. Purification by column chromatography with dichloromethane as the eluent yields the desired product in a yield of 29%, 900 mg.

Provenance & Evidence