3-Bromo-7-methoxy-1-naphthonitrile → 7-Methoxy-3-(3-methoxyphenyl)-1-naphthonitrile

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Reaction Steps

The compound is prepared by the reaction of 3-bromo-7-methoxy-1-naphthonitrile (1.4 g, 1.76 mmol, 1 eq) with 3-methoxyphenylboric acid (320 mg, 2.11 mmol, 1.2 eq) according to method A in 24 h. Purification by column chromatography with hexane/ethyl acetate 9/1 as the eluent yielded the desired compound in a yield of 53%, 300 mg.

Provenance & Evidence