8-Cyano-6-methoxynaphthalene-2-yl trifluoromethanesulfonate → 3-Methoxy-7-(3-methoxyphenyl)-1-naphthonitrile

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Reaction Steps

The compound is prepared by the reaction of 8-cyano-6-methoxynaphthalene-2-yl trifluoromethanesulfonate (466 mg, 1.4 mmol, 1 eq) with 3-methoxyphenylboric acid (260 mg, 1.7 mmol, 1.2 eq) according to method A over night. Purification by column chromatography with hexane/ethyl acetate 7/3 as the eluent yielded the desired compound in a yield of 25%, 113 mg.

Provenance & Evidence