Morpholine → HCID 59443439, compound

Participants

Reaction Conditions

Reaction Steps

2-Methoxy-6-(3-methoxyphenyl)-1-naphthoic acid (200 mg, 0.65 mmol, 1 eq) is boiled under reflux with 5 ml of thionyl chloride under a nitrogen atmosphere for 30 min according to method E. The residue is dissolved in dry THF and added to 1 ml of morpholine cooled at 0° C. The reaction mixture is boiled under reflux over night. After the solvent has been removed on a rotary evaporator, purification is effected by column chromatography with dichloromethane/methanol 95/5 as the eluent. Characterization of the compound was not effected. The raw product was directly employed for ether cleavage.

Provenance & Evidence