HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum(III) Chloride → 3-(4-Hydroxyphenyl)quinolin-7-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 7-Methoxy-3-(4-methoxyphenyl)quinoline | HCID 59443484 | — |
| Product | 3-(4-Hydroxyphenyl)quinolin-7-ol | HCID 135914665 | 63% |
Reaction Steps
The compound is prepared by reaction of 7-methoxy-3-(4-methoxyphenyl)quinoline (96 mg, 0.37 mmol, 1 eq) with aluminum trichloride (392 mg, 2.95 mmol, 6 eq) according to method F. Purification by column chromatography with dichloromethane/methanol 96/4 as the eluent yields the desired product in a yield of 63%, 55 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546392B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-3b1523321de74abb9bac66c042331f39 |
| Source note | uspto-grants-2013_10 |