HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum(III) Chloride → 3-(3-Hydroxyphenyl)quinolin-7-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 7-Methoxy-3-(3-methoxyphenyl)quinoline | HCID 24827432 | — |
| Product | 3-(3-Hydroxyphenyl)quinolin-7-ol | HCID 135783365 | 76% |
Reaction Steps
The compound is prepared by reaction of 7-methoxy-3-(3-methoxyphenyl)-quinoline (108 mg, 0.40 mmol, 1 eq) with aluminum trichloride (433 mg, 3.26 mmol, 8 eq) according to method F. Purification by column chromatography with dichloromethane/methanol 95/5 as the eluent yields the desired product in a yield of 76%, 73 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546392B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-2884463afbd0406f888a34da25eed644 |
| Source note | uspto-grants-2013_10 |