Boron tribromide → 2-Hydroxy-6-(3-hydroxyphenyl)-N-methyl-1-naphthamide

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Reaction Steps

The compound is prepared by reaction of 2-methoxy-6-(3-methoxyphenyl)-N-methyl-1-naphthamide (250 mg, 0.78 mmol, 1 eq) with boron tribromide solution (3.89 mmol, 5 eq) according to method G. Purification by column chromatography with dichloromethane/methanol 98/2 as the eluent yielded the desired product in a yield of 95%, 217 mg.

Provenance & Evidence