Boron tribromide → (2-Hydroxy-6-(3-hydroxyphenyl)naphthalene-1-yl)(piperazin-1-yl)methanone

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Reaction Steps

The compound is prepared by reaction of tert-butyl 4-(2-methoxy-6-(3-methoxyphenyl)-1-naphthoyl)piperazine-1-carboxylate (200 mg, 0.42 mmol, 1 eq) with boron tribromide solution (2.5 ml, 2.52 mmol, 6 eq) according to method G. Purification by column chromatography was not necessary. Extraction of the aqueous phase with ethyl acetate yields the desired product in a yield of 60%, 88 mg.

Provenance & Evidence