Hydrochloric Acid → HCID 25072939, compound

Participants

Reaction Steps

The compound was prepared by refluxing 3-(2-methoxy-6-(3-methoxyphenyl)-naphthalene-1-yl)-N-(methylsulfonyl)benzamide (80 mg, 0.17 mmol, 1 eq) with pyridinium hydrochloride (302 mg, 15 eq) for two hours. After cooling, 2 ml of 1 N HCl was added, and the water phase was extracted with ethyl acetate. The organic phase was dried and concentrated in vacuum. After purification by column chromatography with 10% methanol in dichloromethane, the desired compound was obtained in 42% yield, 31 mg.

Provenance & Evidence