反应详情

0.38 g of 2-[(4-fluorophenyl)acetyl]hydrazinecarbothioamide (1.67 mmol) is added portionwise with stirring. After stirring for 3 hours between 0 and −10° C., water is added dropwise and the mixture is then returned to basic pH with sodium hydroxide, while maintaining a temperature of between 0 and −10° C. The precipitate is filtered off, washed with water and dried. 0.264 g of 5-(4-fluorobenzyl)-1,3,4-thiadiazol-2-amine is obtained.

1. stirringAfter stirring for 3 hours between 0 and −10° C.
2. temperaturewhile maintaining a temperature of between 0 and −10° C
3. filtrationThe precipitate is filtered off
4. washwashed with water
5. customdried