5-Benzyl-1,3,4-thiadiazol-2-amine → Tert-butyl 4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexane-carboxylate

HRID 1035734Notes

Reaction equation

HRID 1035734 reaction equation
[C:1]([O:5][C:6]([CH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:23]([C:30]1[S:34][C:33]([NH2:35])=[N:32][N:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:23]([C:30]1[S:34][C:33]([NH:35][C:18]([C:17]2[CH:21]=[CH:22][C:14]([CH:11]3[CH2:10][CH2:9][CH:8]([C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[CH2:13][CH2:12]3)=[CH:15][CH:16]=2)=[O:19])=[N:32][N:31]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 7548235-Benzyl-1,3,4-thiadiazol-2-amineHCID 667398094-(4-Tert-butoxycarbonylcyclohexyl)benzoic acid

Product 1

HCID 66739876Tert-butyl 4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexane-carboxylate

Procedure

This compound is obtained according to Preparation 11.5. 85 mg of tert-butyl 4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexanecarboxylate are obtained from 4-(4-tert-butoxycarbonylcyclohexyl)benzoic acid and 5-benzyl-1,3,4-thiadiazol-2-amine.

Workup

  1. customThis compound is obtained
  2. customaccording to Preparation 11.5

Sources & evidence

ORD record
ord-8c06ad22f17d4f1bbb07ac2b26c4e15b
Source dataset
uspto-grants-2013_10
Patent number
US08546391B2

Reaction notes

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