Oxalyl chloride → HCID 178501265, compound

HRID 1035740Notes

Reaction equation

HRID 1035740 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16](O)=[O:17])=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)=[O:4].C(Cl)(=O)C([Cl:24])=O>ClCCl.CN(C)C=O>[Cl:24][C:16]([C:15]1[CH:19]=[CH:20][C:12]([O:11][C@@H:8]2[CH2:9][CH2:10][C@H:5]([C:3]([O:2][CH3:1])=[O:4])[CH2:6][CH2:7]2)=[CH:13][CH:14]=1)=[O:17]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 178501272HCID 178501272, compound

Product 1

HCID 178501265HCID 178501265, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

0.350 g of cis-4-(4-methoxycarbonylcyclohexyloxy)benzoic acid (1.26 mmol, 1 eq.) is placed in 13 mL of dichloromethane with stirring, at room temperature, under a nitrogen atmosphere. 0.16 mL of oxalyl chloride (1.89 mmol, 1.5 eq.) and 2 drops of dimethylformamide are successively added. The reaction medium is stirred for 1.5 hours and concentrated under vacuum. The methyl cis-4-(4-chlorocarbonylphenoxy)cyclohexanecarboxylate formed is dissolved in 13 mL of acetonitrile and placed under nitrogen. 0.255 g N-cyclopentyl[1.3.4]thiadiazole-2,5-diamine (1.39 mmol, 1.1 eq.) and 0.12 mL of pyridine (1.51 mmol, 1.2 eq.) are successively added. After 3 days, the medium is filtered and rinsed with acetonitrile to give 0.33 g of methyl cis-4-[4-(5-cyclopentylamino[1.3.4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylate.

Workup

  1. stirringThe reaction medium is stirred for 1.5 hours
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-858c6d5c95fa4c18a7e01bee8a890b1c
Source dataset
uspto-grants-2013_10
Patent number
US08546391B2

Reaction notes

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