HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dimercapto-2,3-butanediol → 1-(2-Morpholin-4-ylethyl)-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dimercapto-2,3-butanediol | HCID 19001 | — |
| Reactant | 2-({[2-(Morpholin-4-yl)ethyl]carbamoyl}amino)-1,3-benzothiazol-6-yl thiocyanate | HCID 86647877 | — |
| Catalyst | Monobasic potassium phosphate | HCID 516951 | — |
| Product | 1-(2-Morpholin-4-ylethyl)-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea | HCID 86647876 | 75.5% |
Reaction Steps
The 1-(2-morpholin-4-ylethyl)-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea was prepared according to the method described in Example 1b, but using 900 mg of 2-{[(2-morpholin-4-ylethyl)carbamoyl]amino}-1,3-benzothiazol-6-yl thiocyanate, 11 mg of potassium dihydrogen phosphate and 1.1 g of DL-dithiothreitol. 633 mg of 1-(2-morpholin-4-ylethyl)-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea are thus obtained in the form of a white solid, the characteristics of which are as follows:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546393B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-374c4364171747029dea54e7d6f6ce14 |
| Source note | uspto-grants-2013_10 |