1,4-Dimercapto-2,3-butanediol → 2-Morpholin-4-ylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamate

HRID 1035757Notes

Reaction equation

HRID 1035757 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10](=[O:24])[NH:11][C:12]2[S:13][C:14]3[CH:20]=[C:19]([S:21]C#N)[CH:18]=[CH:17][C:15]=3[N:16]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.SCC(C(CS)O)O>P([O-])(O)(O)=O.[K+]>[N:1]1([CH2:7][CH2:8][O:9][C:10](=[O:24])[NH:11][C:12]2[S:13][C:14]3[CH:20]=[C:19]([SH:21])[CH:18]=[CH:17][C:15]=3[N:16]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 190011,4-Dimercapto-2,3-butanediolHCID 867070062-Morpholin-4-ylethyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate

Product 1

HCID 867070052-Morpholin-4-ylethyl (6-sulphanyl-1,3-benzothiazol-2-yl)carbamateYield 173.7%

Reagents, catalysts & solvents 1

HCID 516951Monobasic potassium phosphateCatalyst

Procedure

The 2-morpholin-4-ylethyl(6-sulphanyl-1,3-benzothiazol-2-yl)carbamate was prepared according to the method described in Example 1b, but using 547 mg of 2-morpholin-4-ylethyl(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate, 12 mg of potassium dihydrogen phosphate and 1.16 g of DL-dithiothreitol. 885 mg of 2-morpholin-4-ylethyl(6-sulphanyl-1,3-benzothiazol-2-yl)carbamate are thus obtained in the form of a white solid, the characteristics of which are as follows:

Workup

  1. customThe 2-morpholin-4-ylethyl(6-sulphanyl-1,3-benzothiazol-2-yl)carbamate was prepared

Sources & evidence

ORD record
ord-e90e8e27982d4b33ad1d0e413f093625
Source dataset
uspto-grants-2013_10
Patent number
US08546393B2

Reaction notes

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