1,4-Dimercapto-2,3-butanediol → HCID 86647884, compound

HRID 1035761Notes

Reaction equation

HRID 1035761 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][C:10]([NH:12][C:13]2[S:14][C:15]3[CH:21]=[C:20]([S:22]C#N)[CH:19]=[CH:18][C:16]=3[N:17]=2)=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.P([O-])(O)(O)=O.[K+].SCC(C(CS)O)O>>[N:1]1([CH2:7][CH2:8][CH2:9][C:10]([NH:12][C:13]2[S:14][C:15]3[CH:21]=[C:20]([SH:22])[CH:19]=[CH:18][C:16]=3[N:17]=2)=[O:11])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 190011,4-Dimercapto-2,3-butanediolHCID 516951Monobasic potassium phosphateHCID 86647885HCID 86647885, compound

Product 1

HCID 86647884HCID 86647884, compoundYield 8.4%

Procedure

The 4-morpholin-4-yl-N-(6-sulphanyl-1,3-benzothiazol-2-yl)butanamide was prepared according to the method described in Example 1b, but using 906 mg of 4-morpholin-4-yl-N-(6-thiocyanato-1,3-benzothiazol-2-yl]butanamide, 14 mg of potassium dihydrogen phosphate and 1.12 g of DL-dithiothreitol. 71 mg of 4-morpholin-4-yl-N-(6-sulphanyl-1,3-benzothiazol-2-yl)butanamide are thus obtained in the form of a white solid, the characteristics of which are as follows:

Workup

  1. customThe 4-morpholin-4-yl-N-(6-sulphanyl-1,3-benzothiazol-2-yl)butanamide was prepared

Sources & evidence

ORD record
ord-635b0a03da0f469db3d98800e72ab40e
Source dataset
uspto-grants-2013_10
Patent number
US08546393B2

Reaction notes

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