化工社化工社 化学情報印刷レポート · 研究参考用
Dioxindole → 3-Amino-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dioxindole | HCID 6097 | — |
| 反応物 | Sulfuryl chloride | HCID 24648 | — |
| 反応物 | 2,4-Dimethoxybenzenesulfonyl chloride | HCID 2734626 | — |
| 反応物 | HCID 67087479 | HCID 67087479 | — |
| 生成物 | 3-Amino-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one | HCID 67087429 | — |
| 生成物 | HCID 67087479 | HCID 67087479 | — |
反応手順
3-Amino-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one was prepared in analogy to example 1.1 to 1.3 using 5-chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one as 3-hydroxy-1,3-dihydroindol-2-one IV and 2,4-dimethoxyphenylsulfonyl chloride as sulfonyl chloride VII. 5-Chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one was prepared in analogy to example a.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08546401B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-c399ac0e901b4120806c7739a430e13c |
| 出典メモ | uspto-grants-2013_10 |