HRID1035844

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6097

3-Hydroxy-2-oxoindole

C8H7NO2

HCID7369

Benzenesulfonyl chloride

C6H5ClO2S

HCID24648

Sulfuryl chloride

Cl2O2S

结构：CCOc1ncccc1C1(O)C(=O)Nc2cc(F)c(Cl)cc21

HCID67087479

未命名化合物

PRODUCTS

生成物

HCID67087479

未命名化合物

结构：CCOc1ncccc1C1(N)C(=O)N(S(=O)(=O)c2ccccc2)c2cc(F)c(Cl)cc21

HCID67087684

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to example 1.1 to 1.3 using 5-chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one as 3-hydroxy-1,3-dihydroindol-2-one IV and phenylsulfonyl chloride as sulfonyl chloride VII. 5-Chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one was prepared in analogy to example a.1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-21f9f38ceb3a4e1d952c34bcdfdd14ec
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546401B2
来源说明: uspto-grants-2013_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6](=[O:12])[C:5]2([C:14]1[C:15]([O:20][CH2:21][CH3:22])=[N:16][CH:17]=[CH:18][CH:19]=1)[OH:13].OC1C2C(=CC=CC=2)[NH:26]C1=O.[C:34]1([S:40](Cl)(=[O:42])=[O:41])[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.S(Cl)(Cl)(=O)=O>>[NH2:26][C:5]1([C:14]2[C:15]([O:20][CH2:21][CH3:22])=[N:16][CH:17]=[CH:18][CH:19]=2)[C:4]2[C:8](=[CH:9][C:10]([F:11])=[C:2]([Cl:1])[CH:3]=2)[N:7]([S:40]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)(=[O:42])=[O:41])[C:6]1=[O:12].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6](=[O:12])[C:5]2([C:14]1[C:15]([O:20][CH2:21][CH3:22])=[N:16][CH:17]=[CH:18][CH:19]=1)[OH:13]