Acetyl chloride → HCID 51000758, compound

HRID 1035857Notes

Reaction equation

[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[CH:7]=[C:8]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]3[C:31](=[O:32])[C:30]4[C:25](=[CH:26][C:27]([O:35][CH3:36])=[C:28]([O:33][CH3:34])[CH:29]=4)[O:24][CH:23]=3)[CH2:14][CH2:13]2)[CH:9]=[CH:10][CH:11]=1>>[CH3:34][O:33][C:28]1[CH:29]=[C:30]2[C:25](=[CH:26][C:27]=1[O:35][CH3:36])[O:24][CH:23]=[C:22]([CH2:21][CH2:20][CH2:19][CH2:18][N:15]1[CH2:16][CH2:17][N:12]([C:8]3[CH:7]=[C:6]([NH:5][C:1](=[O:3])[CH3:2])[CH:11]=[CH:10][CH:9]=3)[CH2:13][CH2:14]1)[C:31]2=[O:32]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 51000918HCID 51000918, compound

Product 1

HCID 51000758HCID 51000758, compound

Procedure

In a similar manner to Example 13, but using acetyl chloride and 3-{4-[4-(3-aminophenyl)-piperazin-1-yl]-butyl}-6,7-dimethoxychromen-4-one obtained in Example 12, N-(3-{4-[4-(6,7-dimethoxy-4-oxo-4H-chromen-3-yl)-butyl]-piperazin-1-yl}-phenyl)-acetamide is obtained.

Sources & evidence

ORD record: ord-f44aee6373964c7cb3234e2b299292cd
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546402B2

Reaction notes

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