Methyl chloroformate → HCID 51000759, compound

HRID 1035858Notes

Reaction equation

Cl[C:2]([O:4][CH3:5])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][CH2:22][C:23]3[C:32](=[O:33])[C:31]4[C:26](=[CH:27][C:28]([O:36][CH3:37])=[C:29]([O:34][CH3:35])[CH:30]=4)[O:25][CH:24]=3)[CH2:15][CH2:14]2)[CH:10]=[CH:11][CH:12]=1>>[CH3:35][O:34][C:29]1[CH:30]=[C:31]2[C:26](=[CH:27][C:28]=1[O:36][CH3:37])[O:25][CH:24]=[C:23]([CH2:22][CH2:21][CH2:20][CH2:19][N:16]1[CH2:15][CH2:14][N:13]([C:9]3[CH:8]=[C:7]([NH:6][C:2](=[O:3])[O:4][CH3:5])[CH:12]=[CH:11][CH:10]=3)[CH2:18][CH2:17]1)[C:32]2=[O:33]

Participants

Reactant 2

HCID 6586Methyl chloroformate

HCID 51000918HCID 51000918, compound

Product 1

HCID 51000759HCID 51000759, compound

Procedure

In a similar manner to Example 13, but using methyl chloroformate and 3-{4-[4-(3-aminophenyl)-piperazin-1-yl]-butyl}-6,7-dimethoxychromen-4-one obtained in Example 12, methyl (3-{4-[4-(6,7-dimethoxy-4-oxo-4H-chromen-3-yl)-butyl]-piperazin-1-yl}-phenyl)-carbamate is obtained.

Sources & evidence

ORD record: ord-55a13103b74045e58e8ae7b7f8bcec0c
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546402B2

Reaction notes

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