HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → 4-(2-Methoxyethylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide | HCID 25058452 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(2-Methoxyethylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide | HCID 67126520 | — |
Reaction Steps
4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide (1.536 g, 5 mmol), 2-methoxyethanamine (0.376 g, 5 mmol), and triethylamine (1.939 g, 15 mmol) in anhydrous tetrahydrofuran (30 mL) solution was heated at 55° C. for 3 hours. The solution was diluted with ethyl acetate, washed with water and brine, and dried (Na2SO4), filtered and the filtrate was concentrated. The crude material was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546399B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-5c811ca37cea448796730d741d38ac84 |
| Source note | uspto-grants-2013_10 |