HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydroxyindole → HCID 67127040, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydroxyindole | HCID 16054 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Methyl 2,4-Difluorobenzoate | HCID 2782897 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | HCID 67127040 | HCID 67127040 | — |
Reaction Steps
A mixture of 5-hydroxyindole (8.5 g), methyl 2,4-difluorobenzoate (7.05 g), and K3PO4 (9.32 g) in diglyme (40 mL) at 115° C. was stirred for 24 hours. The reaction was cooled, diluted with ether (600 mL), and washed twice with water, and brine, and concentrated. The crude product was chromatographed on silica gel with 2-50% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546399B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-411b734ae6ee48dcbca89121e53ede05 |
| Source note | uspto-grants-2013_10 |