Ammonia → 3-Cyano-4-fluorobenzene-1-sulfonamide

HRID 1035891노트

반응식

HRID 1035891 반응식
[C:1]([C:3]1[CH:4]=[C:5]([S:10](Cl)(=[O:12])=[O:11])[CH:6]=[CH:7][C:8]=1[F:9])#[N:2].[NH3:14]>O1CCOCC1.CO>[C:1]([C:3]1[CH:4]=[C:5]([S:10]([NH2:14])(=[O:12])=[O:11])[CH:6]=[CH:7][C:8]=1[F:9])#[N:2]

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 27789083-Cyano-4-fluorobenzenesulfonyl chloride

생성물 1

HCID 251398973-Cyano-4-fluorobenzene-1-sulfonamide

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

3-Cyano-4-fluorobenzene-1-sulfonyl chloride (1.1 g) in 1,4-dioxane (10 mL) at 0° C. was treated dropwise with a 7 M ammonia solution in methanol (3.57 mL) and stirred for 30 minutes. A small amount of solid was removed by filtration and discarded. The filtrate was concentrated, diluted with ethyl acetate, washed with water and brine, dried (MgSO4), filtered, concentrated and triturated with diethyl ether to give the product.

후처리

  1. customA small amount of solid was removed by filtration
  2. concentrationThe filtrate was concentrated
  3. additiondiluted with ethyl acetate
  4. washwashed with water and brine
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customtriturated with diethyl ether
  9. customto give the product

출처 및 근거

ORD 기록
ord-0afc8fffee6845eeb00c0680c433e4ce
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546399B2

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