Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-Butyn-1-ol, 4-chloro- | HCID 202775 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Morpholinobut-2-YN-1-OL | HCID 3112849 | — |
Reaction Steps
To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the pure title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08546399B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-ade1794cc1de4d388200d5362c2e25c5 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
