Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 67127200 | HCID 67127200 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 67126953 | HCID 67126953 | — |
Reaction Steps
To a solution of EXAMPLE 70B (90 mg) in ethanol (2 mL) was added tetrahydrofuran (2 mL), hydrogen peroxide (30%, 1 mL) and 1M sodium hydroxide solution (0.48 mL), followed by an additional 2 mL of tetrahydrofuran. The reaction was heated to 45° C. for 30 minutes, cooled, and then quenched with 5% HCl solution and extracted twice with dichloromethane. The extracts were combined and concentrated to obtain the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08546399B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-2fb2a3a724194aeb8712bf2aa77e4237 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
